                         SEQUENCE LISTING

<110>  Davis, Simon C.
       Jenne, Stephane J.
       Krebber, Anke
       Huisman, Gjalt W.
       Newman, Lisa M.
 
<120>  IMPROVED KETOREDUCTASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES

<130>  15077WO03 0190.310WO

<150>  60/494,195
<151>  2003-08-11

<150>  60/545,682
<151>  2004-02-18

<160>  542   

<170>  PatentIn version 3.2

<210>  1
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Based upon the ketoreductase of Candida magnoliae


<220>
<221>  misc_feature
<223>  CR2-05orf

<220>
<221>  CDS
<222>  (1)..(852)

<400>  1
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  2
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Based upon the ketoreductase of Candida magnoliae

<400>  2

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  3
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (krh002)

<220>
<221>  CDS
<222>  (1)..(855)

<400>  3
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca agg aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gtg gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag tat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  4
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  4

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  5
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  5
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca agg aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gtg gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag tat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  6
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  6

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  7
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  7
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc caa gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gga aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Gly Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  8
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  8

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Gly Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  9
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  9
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca agg aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aag gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  10
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  10

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  11
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  11
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  12
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  12

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  13
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  13
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  14
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  14

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  15
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  15
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac gag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat tta ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Leu Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  16
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  16

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Leu Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  17
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  17
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc caa gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  18
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  18

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  19
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  19
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca ggg ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  20
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  20

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  21
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  21
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag ggt aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc atc agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  22
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  22

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  23
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  23
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gcg ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta ata ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gat ata tcc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Asp Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  24
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  24

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Asp Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  25
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  25
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc ggg ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt aaa gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Lys Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc atc agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag ttg gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  26
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  26

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Lys Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  27
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  27
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttc gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tat gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt acg gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc aaa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  28
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  28

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  29
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  29
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gcc ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tac      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat atc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc atc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Ile Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  30
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  30

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Ile Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  31
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  31
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc ggt ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gta agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Val Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  32
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  32

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Val Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  33
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  33
atg gta aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Val Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag acc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca acg gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  34
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  34

Met Val Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  35
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  35
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc aac agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Asn Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga tat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Tyr Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  36
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  36

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Asn Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Tyr Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  37
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  37
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat ata gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Ile Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta att ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtt ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gat aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Asp Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  38
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  38

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Ile Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Asp Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  39
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  39
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc aat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asn Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  40
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  40

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asn Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  41
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  41
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gtg tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga ggc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Gly Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc ctt gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser Leu Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cgt tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Arg Leu Asp         
            100                 105                 110                 

ata gta gtt gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

tat gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Tyr Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  42
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  42

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Gly Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Leu Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Arg Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Tyr Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  43
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  43
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta tgt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Cys Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  44
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  44

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Cys Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  45
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  45
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac ttc      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Phe         
    130                 135                 140                         

aag gga gta gga tac gta gca aag caa gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Gln Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  46
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  46

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Phe 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Gln Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  47
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  47
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag aac tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  48
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  48

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  49
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  49
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac cta gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Leu Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  50
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  50

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Leu Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  51
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  51
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac atg cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Met His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  52
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  52

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Met His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  53
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  53
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gca gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Ala Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat tta agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  54
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  54

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Ala Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  55
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  55
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc tgc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asp Ala         
                85                  90                  95              

gtc aag cat aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys His Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  56
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  56

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asp Ala 
                85                  90                  95      


Val Lys His Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  57
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  57
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc ggt cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata gta gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  58
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  58

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  59
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  59
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta cat gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu His Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  60
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  60

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu His Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  61
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  61
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta agg gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aag aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  62
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  62

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  63
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  63
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gga       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Gly         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttc gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  64
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  64

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Gly 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  65
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  65
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat aca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Thr         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga ata aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc cga gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  66
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  66

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Thr 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  67
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  67
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg cat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp His         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gag gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Glu Ala         
                85                  90                  95              

gtc aag caa aca gta gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Val Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  68
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  68

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp His 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Glu Ala 
                85                  90                  95      


Val Lys Gln Thr Val Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  69
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  69
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gta tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Val Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cac ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  70
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  70

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Val Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  71
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  71
atg gca aag aat ttc agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aaa agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Lys Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga ggt gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  72
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  72

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Lys Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  73
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  73
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gtt aca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Thr Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aac      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  74
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  74

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Thr Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  75
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  75
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc caa gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat tat agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga act      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  76
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  76

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  77
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  77
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  78
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  78

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  79
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  79
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata cag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Gln Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  80
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  80

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Gln Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  81
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  81
atg gca gag aat tgt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Glu Asn Cys Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  82
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  82

Met Ala Glu Asn Cys Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  83
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  83
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta ata gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

agg gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Arg Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  84
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  84

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Arg Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  85
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  85
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat atc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  86
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  86

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  87
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  87
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa gca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gct aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  88
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  88

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  89
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  89
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta agg gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa gca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aga aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  90
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  90

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  91
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  91
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta ata gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gac gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  92
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  92

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  93
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  93
atg gca gag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca gat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  94
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  94

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  95
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  95
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc aac agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat agc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga gca tta gta ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gtg aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc gta agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  96
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  96

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  97
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  97
atg gca aag aat ttt agc aat gta gag tat ccc gca ccc ccc ccc gca       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat aca aag aat gag agc tta caa gta tta gat tta ttt aag tta aat       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

gga aaa gta gca agc ata aca gga agc agc agc gga ata gga tat gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

tta gca gag gct ttt gca caa gtc gga gca gat gta gca ata tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aat ggc cat gat gca aca gga aaa gca gag gca tta gca aag aag tat      240
Asn Gly His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

gga gta aag gta aag gca tat aaa gca aat gta agc agc agc gat gca      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtc aag caa aca ata gag caa caa ata aag gat ttt gga cat tta gat      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gta gta gca aat gca gga ata ccc tgg aca aag gga gca tat ata      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat caa gat gat gac aag cat ttt gac caa gta gta gat gta gac tta      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag gga gta gga tac gta gca aag cat gca gga agg cat ttt agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

agg ttt gag aaa gag gga aaa aag gga tcc tta att ttt aca gca agc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ser Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg agc gga cat ata gta aat gtc ccc caa ttc caa gca aca tat aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gca gca aag gca gga gta agg cat ttt gca aag agc tta gca gtc gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gca ccc ttt gca agg gta aat agc atc agc ccc gga tat ata aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

aca gag ata agc gat ttc gtc ccc caa gag aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc ccc tta gga agg gga gga gag aca gca gag tta gta gga      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gca tat tta ttc tta gca agc gat gca gga agc tat gca aca gga aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat ata ata gta gat gga gga tat aca tta ccc taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  98
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  98

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Gly His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ser Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  99
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  99
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  100
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  100

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  101
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  101
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  102
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  102

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  103
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  103
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc agg gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  104
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  104

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  105
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  105
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tgt agt aat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asn Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  106
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  106

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asn Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  107
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  107
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc tac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Tyr Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  108
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  108

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Tyr Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  109
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  109
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ttg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  110
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  110

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  111
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(855)

<400>  111
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  112
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  112

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  113
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  113
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat atg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Met His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  114
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  114

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Met His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  115
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  115
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  116
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  116

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  117
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  117
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc tgc ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Cys Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  118
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  118

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Cys Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  119
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  119
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  120
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  120

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  121
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  121
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa act ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gtg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Val Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tcc gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aga gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  122
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  122

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Val Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  123
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  123
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  124
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  124

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  125
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  125
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttc cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gtg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Val Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gac atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Asp Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  126
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  126

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Val Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Asp Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  127
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  127
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat atg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Met His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  128
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  128

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Met His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  129
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  129
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc agg gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gct ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  130
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  130

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  131
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  131
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa act ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gac atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Asp Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  132
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  132

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Asp Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  133
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  133
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa act ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  134
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  134

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  135
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  135
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  136
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  136

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  137
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  137
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tgt agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gac atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Asp Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  138
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  138

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Asp Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  139
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  139
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  140
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  140

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  141
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  141
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc agg gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aga gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  142
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  142

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  143
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  143
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  144
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  144

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  145
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  145
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  146
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  146

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  147
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  147
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  148
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  148

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  149
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  149
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  150
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  150

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  151
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  151
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tcc agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aag aag ggc gca ttg gtc tgt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Cys Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gtc tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  152
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  152

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Cys Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  153
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  153
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  154
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  154

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  155
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  155
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gca tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgc agt gac gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  156
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  156

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  157
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  157
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat cta agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aag aag ggc tca ttg atc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ser Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac atc ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc act gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Thr Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat att gtc gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  158
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  158

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ser Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Thr Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  159
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  159
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgc agt gaa gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat cta aag gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Lys Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

aca tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gtc tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gtg agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Val Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat att atc gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  160
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  160

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Lys Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Val Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  161
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  161
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

tac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Tyr Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  162
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  162

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Tyr Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  163
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  163
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tcc agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gtg agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Val Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  164
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  164

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Val Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  165
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  165
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aga gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  166
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  166

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  167
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  167
atg gct aaa aac ttt agc aat gtc gaa tat cct gtc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Val Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc agg gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  168
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  168

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Val Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  169
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  169
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa act ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc agg gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  170
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  170

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  171
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  171
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  172
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  172

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  173
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  CDS
<222>  (1)..(855)

<220>
<221>  misc_feature
<222>  (1)..(855)
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<400>  173
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa gac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct ata tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  174
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  174

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Ile Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  175
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  175
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gac ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  176
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  176

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  177
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  177
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa gct gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Ala Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  178
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  178

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Ala Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  179
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  179
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gcc aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  180
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  180

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  181
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  181
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttt gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac aca ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  182
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  182

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  183
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  183
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc agg gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  184
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  184

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Arg Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  185
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  185
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  186
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  186

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  187
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  187
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aga gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  188
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  188

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  189
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(855)

<400>  189
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ctc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Leu Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  190
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  190

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Leu Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  191
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  191
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aaa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  192
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  192

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Lys Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  193
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  193
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gac ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg aga gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  194
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  194

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  195
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  195
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  196
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  196

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  197
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(855)

<400>  197
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tgt agt gag gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Glu Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc tgc ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly Cys Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cac gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  198
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  198

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Glu Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly Cys Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  199
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  199
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc ata aac gaa act ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Ile Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tgt agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asp Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cgc ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly Arg Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  200
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  200

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Ile Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Cys Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly Arg Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  201
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  201
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cag gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Gln Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  202
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  202

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Glu His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Gln Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  203
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(855)

<400>  203
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aag cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  204
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  204

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  205
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  205
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg aga gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  206
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  206

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  207
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  207
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa aga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro     Arg                     
        275                 280                                         


<210>  208
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  208

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  209
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  krh271

<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  209
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa act ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cgc ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Arg Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tcc cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc ggc atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  210
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  210

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Thr Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly Arg Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Gly Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  211
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  211
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac caa gtg gta gac gtc gac ttc      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Phe         
    130                 135                 140                         

aag ggc gta ggc tat gta gca aaa tac gcg ggt cgc cat tat aag gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Tyr Lys Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg cgg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Arg                             
        275                 280                                         


<210>  212
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  212

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Phe 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Tyr Ala Gly Arg His Tyr Lys Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Arg 
        275                 280             


<210>  213
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  213
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aag aag ggc gca tta atc tgt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Cys Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  214
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  214

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Ile Cys Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  215
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  215
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc aag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Lys Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  216
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  216

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Lys Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  217
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  217
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt ggc agt tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Gly Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cac gcg gta gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys His Ala Val Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat cta agg gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtc ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  218
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  218

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Gly Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys His Ala Val Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  219
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  219
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc cca ccg cca gtt       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Val         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gcc ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  220
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  220

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Val 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  221
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  221
atg gcg aag aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca ggt       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Gly         
1               5                   10                  15              

cat acc aaa aac gaa agt ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gca tct atc acc ggt ggc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Gly Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  222
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  222

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Gly 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Gly Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  223
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(855)

<400>  223
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  224
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  224

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  225
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  225
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc atc ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttc cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gga aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Gly Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  226
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  226

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Gly Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  227
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  227
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aag gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgc agt gaa gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala         
                85                  90                  95              

gtg aaa ctg act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Leu Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc ccg tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc aac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asn Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  228
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  228

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala 
                85                  90                  95      


Val Lys Leu Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asn Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  229
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  229
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gcc ttt gcg cag gtt ggc gcg gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

tac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Tyr Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gaa atc tct gat ttc gtc ccg caa gga aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat att atc gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  230
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  230

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Tyr Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  231
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  231
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tcg ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gac cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gtg ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

aca tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  232
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  232

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  233
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  233
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgc agt gaa gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

aca tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  234
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  234

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  235
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  235
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgc agt gaa gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat gtg cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gcg cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gag tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat att atc gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  236
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  236

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Val His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  237
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  237
atg gct gaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgc agt gaa gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gtc tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  238
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  238

Met Ala Glu Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Glu Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  239
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  239
atg gct aaa aac ctt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Leu Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa aat ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tgt agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aga aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat att atc gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  240
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  240

Met Ala Lys Asn Leu Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Asn Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Cys Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Arg Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  241
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  241
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  242
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  242

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  243
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  243
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act agg ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Arg Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  244
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  244

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Arg Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  245
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  245
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca agg tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Arg Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gac gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  246
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  246

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Arg Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  247
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  247
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cac ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gac gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  248
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  248

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  249
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  249
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gga      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  250
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  250

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  251
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  251
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  252
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  252

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  253
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  253
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  254
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  254

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  255
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  255
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  256
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  256

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  257
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  257
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  258
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  258

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  259
<211>  855
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(855)

<400>  259
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa tga                  855
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  260
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  260

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  261
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  261
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  262
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  262

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  263
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  263
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc gtc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Val Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  264
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  264

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Val Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  265
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  265
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt tac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly Tyr Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc gca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Ala         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  266
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  266

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly Tyr Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Ala 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  267
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  267
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gtg gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtc aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  268
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  268

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  269
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  269
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gct ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Ala Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt tcc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Ser Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aac      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  270
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  270

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Ala Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Ser Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  271
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  271
atg gct aaa aac ttt agc aac gtc gaa tac cct gcc ccg ccg ccg gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  272
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  272

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  273
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  273
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  274
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  274

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  275
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  275
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtc cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  276
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  276

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  277
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  277
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag acc att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aac      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgc cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtc ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  278
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  278

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  279
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  279
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg ccg gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag gtc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Val Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  280
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  280

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Val Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  281
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  281
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gat ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Asp Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  282
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  282

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Asp Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  283
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  283
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttc acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gga aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggc      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  284
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  284

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  285
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  285
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gca      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aga cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Arg His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gga      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  286
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  286

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Arg His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  287
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  287
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca aag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Lys Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  288
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  288

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Lys Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  289
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  289
atg gct aaa aac ttt agc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gga      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  290
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  290

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  291
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  291
atg gct aaa aac ttt agc aat gtc gaa tac ccc gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att agt      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Ser         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  292
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  292

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Ser 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  293
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  293
atg gct aaa aac ttt agc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag acc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Thr Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc tat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg Tyr Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  294
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  294

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Thr Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg Tyr Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  295
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  295
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act atc gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gcg tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  296
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  296

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  297
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  297
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat gcc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Ala Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc aca ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gcc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Ala Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggc      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  298
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  298

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Ala Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Ala Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  299
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  299
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gcc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Ala Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  300
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  300

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Ala Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  301
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  301
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  302
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  302

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  303
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh461\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  303
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  304
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  304

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  305
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh463\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  305
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gag aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gct ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Ala Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  306
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  306

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Ala Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  307
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh464\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  307
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat gcc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Ala Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  308
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  308

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Ala Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  309
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh4650-rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  309
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc ctt ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Leu Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtc ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gga      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc ctt gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Leu Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  310
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  310

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Leu Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Leu Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  311
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  311
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gca gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Ala Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aag tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  312
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  312

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Ala Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  313
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh468\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  313
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aag gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

acg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  314
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  314

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Thr Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  315
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh470\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  315
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

agc agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tac      240
Ser Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac ctg gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Leu Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cga gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  316
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  316

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Ser Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Leu Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  317
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh473\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  317
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa gac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  318
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  318

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  319
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh474\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  319
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc agg gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gta      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  320
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  320

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  321
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh475\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  321
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  322
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  322

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  323
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh476\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  323
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa gac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gcg aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  324
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  324

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  325
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh477\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  325
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ctt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu         
145                 150                 155                 160         

cgt tac gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Tyr Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gac gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  326
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  326

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Leu Arg Glu 
145                 150                 155                 160 


Arg Tyr Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  327
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae (rh478\rc)

<220>
<221>  CDS
<222>  (1)..(852)

<400>  327
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttc ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  328
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  328

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  329
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  329
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gct ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Ala Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  330
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  330

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Ala Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  331
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  331
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa tat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Tyr Lys Trp Trp         
225                 230                 235                 240         

agc ttg gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  332
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  332

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Tyr Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  333
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  333
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gcc tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtt aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gag aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  334
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  334

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  335
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  335
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gca ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Ala Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc ccg tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  336
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  336

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Ala Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  337
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  337
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtc gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gga      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gta gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  338
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  338

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Gly 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  339
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  339
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat gcc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Ala Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  340
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  340

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Ala Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  341
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  341
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa gac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gcc ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cag gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg att gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat tat cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc ata aag ggc gcc ttg att ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser         
                165                 170                 175             

gtg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  342
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  342

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser Gln Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Ile Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Tyr Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Ile Lys Gly Ala Leu Ile Phe Thr Ala Ser 
                165                 170                 175     


Val Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  343
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  laboratory generated variant based upon the ketoreductase of 
       Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  343
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  344
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  344

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  345
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  345
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ccg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Pro Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc ccg tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gag      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  346
<211>  283
<212>  PRT
<213>  Artifical

<400>  346

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Pro Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  347
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  347
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt tat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att agt      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Ser         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgc ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  348
<211>  283
<212>  PRT
<213>  Artifical

<400>  348

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Tyr Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Ser 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  349
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  349
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc agc tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

gac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asp Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cac ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gag aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  350
<211>  283
<212>  PRT
<213>  Artifical

<400>  350

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Ser Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asp Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  351
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  351
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

gac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aga tat      240
Asp Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Arg Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgc cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc atc gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  352
<211>  283
<212>  PRT
<213>  Artifical

<400>  352

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asp Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Arg Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  353
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(852)

<400>  353
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  354
<211>  283
<212>  PRT
<213>  Artifical

<400>  354

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  355
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  355
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa caa gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys Gln Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  356
<211>  283
<212>  PRT
<213>  Artifical

<400>  356

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys Gln Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  357
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  357
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac aaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  358
<211>  283
<212>  PRT
<213>  Artifical

<400>  358

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  359
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  359
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aag ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttc gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc aaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Lys Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  360
<211>  283
<212>  PRT
<213>  Artifical

<400>  360

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Lys Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  361
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  361
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  362
<211>  283
<212>  PRT
<213>  Artifical

<400>  362

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  363
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  363
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggc cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttt gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  364
<211>  283
<212>  PRT
<213>  Artifical

<400>  364

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  365
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  365
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gag      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  366
<211>  283
<212>  PRT
<213>  Artifical

<400>  366

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  367
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  367
atg gct aaa aac ttt tcc aag gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Lys Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  368
<211>  283
<212>  PRT
<213>  Artifical

<400>  368

Met Ala Lys Asn Phe Ser Lys Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  369
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  369
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gga aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Gly Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  370
<211>  283
<212>  PRT
<213>  Artifical

<400>  370

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Gly Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  371
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  371
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

ggt cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Gly Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc cta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  372
<211>  283
<212>  PRT
<213>  Artifical

<400>  372

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Gly Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  373
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  373
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

aat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asn Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  374
<211>  283
<212>  PRT
<213>  Artifical

<400>  374

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asn Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  375
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  375
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt ggt gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Gly Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  376
<211>  283
<212>  PRT
<213>  Artifical

<400>  376

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Gly Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  377
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  377
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  378
<211>  283
<212>  PRT
<213>  Artifical

<400>  378

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  379
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  379
atg gct aaa aac ttt tcc aat gtc gaa tat cca gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca ggg gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Gly Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggg aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  380
<211>  283
<212>  PRT
<213>  Artifical

<400>  380

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Gly Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  381
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  381
atg gct aaa aac ttt tcc aat gtc aaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  382
<211>  283
<212>  PRT
<213>  Artifical

<400>  382

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  383
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  383
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gtt       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Val         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt ggc cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Gly Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgc gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  384
<211>  283
<212>  PRT
<213>  Artifical

<400>  384

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Val 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Gly Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  385
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  385
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  386
<211>  283
<212>  PRT
<213>  Artifical

<400>  386

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  387
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  387
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aag gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gtt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Val Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  388
<211>  283
<212>  PRT
<213>  Artifical

<400>  388

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Val Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  389
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  389
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cgt acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
Arg Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  390
<211>  283
<212>  PRT
<213>  Artifical

<400>  390

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


Arg Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  391
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae

<220>
<221>  CDS
<222>  (1)..(852)

<400>  391
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt ggc cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Gly Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  392
<211>  283
<212>  PRT
<213>  Artifical

<400>  392

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Gly Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  393
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  393
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cga gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  394
<211>  283
<212>  PRT
<213>  Artifical

<400>  394

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  395
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  395
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt ggc cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Gly Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  396
<211>  283
<212>  PRT
<213>  Artifical

<400>  396

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Gly Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  397
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  397
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gtt gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Val Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gga ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Gly Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gcg agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  398
<211>  283
<212>  PRT
<213>  Artifical

<400>  398

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Val Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Gly Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  399
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 


<220>
<221>  CDS
<222>  (1)..(852)

<400>  399
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  400
<211>  283
<212>  PRT
<213>  Artifical

<400>  400

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  401
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  401
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc agg gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gta      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  402
<211>  283
<212>  PRT
<213>  Artifical

<400>  402

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  403
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  403
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cac gac gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aag gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc agg gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gta      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  404
<211>  283
<212>  PRT
<213>  Artifical

<400>  404

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  405
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  405
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aga cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Arg Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gtt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Val Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  406
<211>  283
<212>  PRT
<213>  Artifical

<400>  406

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Arg Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Val Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  407
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  407
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aag cag act att gag cgg cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Arg Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gac cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttc acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  408
<211>  283
<212>  PRT
<213>  Artifical

<400>  408

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Arg Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  409
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  409
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat aac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asn Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gtg tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  410
<211>  283
<212>  PRT
<213>  Artifical

<400>  410

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asn Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  411
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  411
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac aaa tca ctg cag gta ctg gat ctg ttc aaa ctg gac       96
His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asp         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  412
<211>  283
<212>  PRT
<213>  Artifical

<400>  412

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asp 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  413
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  413
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gag gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa aaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Lys Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  414
<211>  283
<212>  PRT
<213>  Artifical

<400>  414

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Lys Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  415
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  415
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  416
<211>  283
<212>  PRT
<213>  Artifical

<400>  416

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  417
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  417
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cgg act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Arg Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  418
<211>  283
<212>  PRT
<213>  Artifical

<400>  418

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Arg Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  419
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  419
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca ggg gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Gly Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agt tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cga gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  420
<211>  283
<212>  PRT
<213>  Artifical

<400>  420

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Gly Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  421
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  421
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gta      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  422
<211>  283
<212>  PRT
<213>  Artifical

<400>  422

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  423
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  423
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gcg cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  424
<211>  283
<212>  PRT
<213>  Artifical

<400>  424

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  425
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  425
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gta      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  426
<211>  283
<212>  PRT
<213>  Artifical

<400>  426

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  427
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  427
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat ggt gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Gly Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  428
<211>  283
<212>  PRT
<213>  Artifical

<400>  428

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Gly Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  429
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  429
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg cca cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aag gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc agg gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp         
            100                 105                 110                 

att gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gta      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  430
<211>  283
<212>  PRT
<213>  Artifical

<400>  430

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Arg Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Val 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  431
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  431
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat ggc gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Gly Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  432
<211>  283
<212>  PRT
<213>  Artifical

<400>  432

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Gly Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  433
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  433
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca aag gcc cta gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Lys Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  434
<211>  283
<212>  PRT
<213>  Artifical

<400>  434

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Lys Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  435
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  435
atg gct aaa aac ttt tcc aat gtc aaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt ggc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Gly Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  436
<211>  283
<212>  PRT
<213>  Artifical

<400>  436

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Gly Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  437
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  437
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  438
<211>  283
<212>  PRT
<213>  Artifical

<400>  438

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  439
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  439
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgc ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac att ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  440
<211>  283
<212>  PRT
<213>  Artifical

<400>  440

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Ile Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  441
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  441
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg cca cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtc ggc gca gac gtt gcg atc tgg tac      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtc gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  442
<211>  283
<212>  PRT
<213>  Artifical

<400>  442

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  443
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  443
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  444
<211>  283
<212>  PRT
<213>  Artifical

<400>  444

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  445
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  445
atg gct aaa aac ttt tcc aat gtc gag tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt ggc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Gly Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac att      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  446
<211>  283
<212>  PRT
<213>  Artifical

<400>  446

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Gly Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  447
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  447
atg gct aaa aac ttt tcc aat gtc aaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  448
<211>  283
<212>  PRT
<213>  Artifical

<400>  448

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  449
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  449
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat gaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Glu Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  450
<211>  283
<212>  PRT
<213>  Artifical

<400>  450

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Glu Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  451
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  451
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  452
<211>  283
<212>  PRT
<213>  Artifical

<400>  452

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  453
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  453
atg gct aaa aac ttt tcc aat gtc gaa tat cca gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gga aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  454
<211>  283
<212>  PRT
<213>  Artifical

<400>  454

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  455
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  455
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aag gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tct      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa gca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Ala Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  456
<211>  283
<212>  PRT
<213>  Artifical

<400>  456

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Ala Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  457
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  457
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gcc aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag gct att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gag      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  458
<211>  283
<212>  PRT
<213>  Artifical

<400>  458

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Ala Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  459
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  459
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aaa caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggt cgt ggt ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gat ggc ggc tac acg ctg ccg taa                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  460
<211>  283
<212>  PRT
<213>  Artifical

<400>  460

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Lys Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  461
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  461
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ctg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Leu Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  462
<211>  283
<212>  PRT
<213>  Artifical

<400>  462

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Leu Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  463
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  463
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  464
<211>  283
<212>  PRT
<213>  Artifical

<400>  464

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  465
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  465
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cgg gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Arg Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggc      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  466
<211>  283
<212>  PRT
<213>  Artifical

<400>  466

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Arg Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  467
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  467
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aag cag act att gag cgg cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Arg Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gac cag gat gac gat aaa cat ttt aac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asn Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttc acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  468
<211>  283
<212>  PRT
<213>  Artifical

<400>  468

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Arg Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asn Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  469
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  469
atg gct aaa aac ttt tcc aat gtc aaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag ggt gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cga gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  470
<211>  283
<212>  PRT
<213>  Artifical

<400>  470

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Gly Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Arg Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  471
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  471
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac aaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aga gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Arg Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  472
<211>  283
<212>  PRT
<213>  Artifical

<400>  472

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Arg Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  473
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  473
atg gct aaa aac ttt tcc aat gtc aaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  474
<211>  283
<212>  PRT
<213>  Artifical

<400>  474

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  475
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  475
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tcc atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gcg ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  476
<211>  283
<212>  PRT
<213>  Artifical

<400>  476

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  477
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  477
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac aaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat aat gcc acc ggt aaa gca gag gcc ctg gct aga aaa tat      240
Asn Ser His Asn Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  478
<211>  283
<212>  PRT
<213>  Artifical

<400>  478

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asn Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  479
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  479
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac aaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tat gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct gat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  480
<211>  283
<212>  PRT
<213>  Artifical

<400>  480

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Lys Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asp Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  481
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  481
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa ctg act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Leu Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttt ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  482
<211>  283
<212>  PRT
<213>  Artifical

<400>  482

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Leu Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  483
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  483
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt aac cag gtg gtg gac gtc aac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asn Gln Val Val Asp Val Asn Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  484
<211>  283
<212>  PRT
<213>  Artifical

<400>  484

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asn Gln Val Val Asp Val Asn Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  485
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  485
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  486
<211>  283
<212>  PRT
<213>  Artifical

<400>  486

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  487
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  487
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac cgc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Arg His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ctc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Leu Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  488
<211>  283
<212>  PRT
<213>  Artifical

<400>  488

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Arg His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Leu Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  489
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  489
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat gaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Glu Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  490
<211>  283
<212>  PRT
<213>  Artifical

<400>  490

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Glu Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  491
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  491
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca agg tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Arg Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  492
<211>  283
<212>  PRT
<213>  Artifical

<400>  492

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Arg Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  493
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  493
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aag gca gag gcc ctg gct aga aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  494
<211>  283
<212>  PRT
<213>  Artifical

<400>  494

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Arg Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  495
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  495
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gcc ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  496
<211>  283
<212>  PRT
<213>  Artifical

<400>  496

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  497
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  497
atg gct aaa aac ttt tcc aat gtc gaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  498
<211>  283
<212>  PRT
<213>  Artifical

<400>  498

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  499
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  499
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa gca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Ala Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  500
<211>  283
<212>  PRT
<213>  Artifical

<400>  500

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Ala Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  501
<211>  852
<212>  DNA
<213>  Artifical


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  501
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  502
<211>  283
<212>  PRT
<213>  Artifical

<400>  502

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  503
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  503
atg gct aaa aac ttt tcc aat gtc gaa tat cct gca ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gat gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  504
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  504

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  505
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  505
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtt gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  506
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  506

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  507
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  507
atg gct aaa aac ttt tcc aat gtc aaa tac cct gcc ccg ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat cta ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt aac cag gtg gtg gac gtc aac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asn Gln Val Val Asp Val Asn Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  508
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  508

Met Ala Lys Asn Phe Ser Asn Val Lys Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asn Gln Val Val Asp Val Asn Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  509
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  509
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa agc gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Ser Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aag ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtt ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  510
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  510

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Ser Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  511
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  511
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  512
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  512

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  513
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  513
atg gct aaa aac ttt tcc aat gtc gaa tac cct gcc cca ccg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  514
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  514

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Pro Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  515
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  515
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc gat aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Asp Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  516
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  516

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Asp Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  517
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  517
atg gct aaa aac ttt tcc aat gtc gaa tac cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gaa aca cag aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  518
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  518

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  519
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  519
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa gac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac att gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  520
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  520

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asp Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  521
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  521
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gcc       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtt gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttc cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  522
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  522

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  523
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  523
atg gct aaa aac ttt tcc aat gtc gaa tac cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgt cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  524
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  524

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  525
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  525
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aag aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gag aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  526
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  526

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  527
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  527
atg gct aaa aac ttt tcc aaa gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Lys Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  528
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  528

Met Ala Lys Asn Phe Ser Lys Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  529
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  529
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  530
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  530

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  531
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  531
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg agc       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Ser         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca caa aat aga tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc aca      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  532
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  532

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Ser 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Arg Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  533
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  533
atg gct aaa aac ttt tcc aat gtc gag tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gca ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gaa aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  534
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  534

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Ala Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  535
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  535
atg gct aaa aac ttt tcc aat gtc gga tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Gly Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa agc gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Ser Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtt gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gga aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  536
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  536

Met Ala Lys Asn Phe Ser Asn Val Gly Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Ser Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Gly Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  537
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  537
atg gct aaa aac ttt tcc aat gtc gga tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Gly Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggc tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtt gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  538
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  538

Met Ala Lys Asn Phe Ser Asn Val Gly Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  539
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  misc_feature
<223>  Based upon the ketoreductase of Candida magnoliae 

<220>
<221>  CDS
<222>  (1)..(852)

<400>  539
atg gct aaa aac ttt tcc aat gtc gaa tat cct gcc ccg gcg cca gct       48
Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggt tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gct ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agt cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtg gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgc ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aat gtg ccg caa ttt cag gcg acc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn         
            180                 185                 190                 

gcg gtc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg cag gag aca caa aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc gtt gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  540
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  540

Met Ala Lys Asn Phe Ser Asn Val Glu Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Thr Tyr Asn 
            180                 185                 190         


Ala Val Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Val Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


<210>  541
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  mutant


<220>
<221>  CDS
<222>  (1)..(852)

<400>  541
atg gct aaa aac ttt tcc aat gtc gga tat cct gcc ccg gcg cca gca       48
Met Ala Lys Asn Phe Ser Asn Val Gly Tyr Pro Ala Pro Ala Pro Ala         
1               5                   10                  15              

cat acc aaa aac gaa tca ctg cag gta ctg gat ctg ttc aaa ctg aac       96
His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn         
            20                  25                  30                  

ggc aaa gtc gcg tct atc acc ggt agc aac tca ggc att ggc tac gcg      144
Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala         
        35                  40                  45                      

ctg gcc gaa gcc ttt gcg cag gtt ggc gca gac gtt gcg atc tgg tat      192
Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr         
    50                  55                  60                          

aac agc cat gat gcc acc ggt aaa gca gag gcc ctg gct aaa aaa tat      240
Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr         
65                  70                  75                  80          

ggc gta aaa gtc aag gct tat aaa gct aat gtc agc tcg agt gat gcg      288
Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala         
                85                  90                  95              

gtg aaa cag act att gag cag cag atc aag gat ttt ggc cac ctg gac      336
Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp         
            100                 105                 110                 

ata gtt gtg gcg aac gca ggc atc cca tgg act aag ggt gca tac atc      384
Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile         
        115                 120                 125                     

gat cag gat gac gat aaa cat ttt gac cag gtg gtt gac gtc gac ctg      432
Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu         
    130                 135                 140                         

aaa ggc gta ggc tat gta gca aaa cat gcg ggt cgc cat ttt cgt gaa      480
Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu         
145                 150                 155                 160         

cgt ttc gaa aaa gaa ggc aaa aag ggc gcc ttg gtc ttt acg gct tcc      528
Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser         
                165                 170                 175             

atg tcg ggt cac atc gtt aac gtg ccg caa ttt cag gcg gcc tac aat      576
Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn         
            180                 185                 190                 

gcg gcc aag gca ggc gtg cgt cat ttc gca aag tcc ctg gcc gtg gaa      624
Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu         
        195                 200                 205                     

ttt gct cct ttc gca cgt gtt aac tct gta tct cct ggc tat att aat      672
Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn         
    210                 215                 220                         

acc gag atc tct gat ttc gtc ccg caa gaa aca cag aat aaa tgg tgg      720
Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp         
225                 230                 235                 240         

agc tta gtt cca ttg ggc cgt ggc ggg gaa act gcg gaa tta gtt ggt      768
Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly         
                245                 250                 255             

gcc tac ctg ttc ctg gca agt gat gcg ggc tcc tac gcc acg ggc acg      816
Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr         
            260                 265                 270                 

gat atc att gtg gac ggc ggc tac acg ctg ccg tag                      852
Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro                             
        275                 280                                         


<210>  542
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  mutant

<400>  542

Met Ala Lys Asn Phe Ser Asn Val Gly Tyr Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


His Thr Lys Asn Glu Ser Leu Gln Val Leu Asp Leu Phe Lys Leu Asn 
            20                  25                  30          


Gly Lys Val Ala Ser Ile Thr Gly Ser Asn Ser Gly Ile Gly Tyr Ala 
        35                  40                  45              


Leu Ala Glu Ala Phe Ala Gln Val Gly Ala Asp Val Ala Ile Trp Tyr 
    50                  55                  60                  


Asn Ser His Asp Ala Thr Gly Lys Ala Glu Ala Leu Ala Lys Lys Tyr 
65                  70                  75                  80  


Gly Val Lys Val Lys Ala Tyr Lys Ala Asn Val Ser Ser Ser Asp Ala 
                85                  90                  95      


Val Lys Gln Thr Ile Glu Gln Gln Ile Lys Asp Phe Gly His Leu Asp 
            100                 105                 110         


Ile Val Val Ala Asn Ala Gly Ile Pro Trp Thr Lys Gly Ala Tyr Ile 
        115                 120                 125             


Asp Gln Asp Asp Asp Lys His Phe Asp Gln Val Val Asp Val Asp Leu 
    130                 135                 140                 


Lys Gly Val Gly Tyr Val Ala Lys His Ala Gly Arg His Phe Arg Glu 
145                 150                 155                 160 


Arg Phe Glu Lys Glu Gly Lys Lys Gly Ala Leu Val Phe Thr Ala Ser 
                165                 170                 175     


Met Ser Gly His Ile Val Asn Val Pro Gln Phe Gln Ala Ala Tyr Asn 
            180                 185                 190         


Ala Ala Lys Ala Gly Val Arg His Phe Ala Lys Ser Leu Ala Val Glu 
        195                 200                 205             


Phe Ala Pro Phe Ala Arg Val Asn Ser Val Ser Pro Gly Tyr Ile Asn 
    210                 215                 220                 


Thr Glu Ile Ser Asp Phe Val Pro Gln Glu Thr Gln Asn Lys Trp Trp 
225                 230                 235                 240 


Ser Leu Val Pro Leu Gly Arg Gly Gly Glu Thr Ala Glu Leu Val Gly 
                245                 250                 255     


Ala Tyr Leu Phe Leu Ala Ser Asp Ala Gly Ser Tyr Ala Thr Gly Thr 
            260                 265                 270         


Asp Ile Ile Val Asp Gly Gly Tyr Thr Leu Pro 
        275                 280             


